Dra. Irene Beatriz Castaño Navarro

Investigadora Titular "C"

Integrante del SNI. Nivel 2

División de Biología Molecular

icastano@ipicyt.edu.mx

Selección de artículos de investigación

Publicaciones en el Science Citation Index

1.- Grecia Hernández-Hernández, Laura A. Vera-Salazar, Leonardo Castanedo, Eunice López-Fuentes, Guadalupe Gutiérrez-Escobedo, Alejandro De Las Peñas, and Irene Castaño "Abf1 is an essential protein that participates in cell cycle progression and subtelomeric silencing in Candida glabrata". JOURNAL OF FUNGI . 2021;

7(12) : 1005

2.- Juan Ernesto López-Ramos, Elihú Bautista, Guadalupe Gutiérrez-Escobedo, Gabriela Mancilla-Montelongo, Irene Castaño, Marco Martín González-Chávez and Alejandro De Las Peñas "Analysis of Volatile Molecules Present in the Secretome of the Fungal Pathogen Candida glabrata". MOLECULES . 2021;

(en impresión (aceptado))

3.- Oscar Hernández-Carreón, Cesia Hernández-Howell, Grecia Hernández-Hernández, M. Selene Herrera-Basurto, Blanca E. González-Gómez, Guadalupe Gutiérrez-Escobedo, Norma I. García-Calderón, Daniel Barrón-Pastor, Alejandro De Las Peñas, Irene Castaño "Highly specific and rapid molecular detection of Candida glabrata in clinical samples". BRAZILIAN JOURNAL OF MICROBIOLOGY . 2021;

52 : 1733-1744

4.- Eunice López-Fuentes, Guadalupe Gutiérrez-Escobedo, Bea Timmermans, Patrick Van Dijck, Alejandro De Las Peñas and Irene Castaño "Candida glabrata¿s genome plasticity confers a unique pattern of expressed cell wall proteins https://doi.org/10.3390/jof4020067 ". JOURNAL OF FUNGI . 2018;

4(2) 67 : 2-16

5.- Eunice López-Fuentes, Grecia Hernández-Hernández, Leonardo Castanedo, Guadalupe Gutiérrez-Escobedo, Katarzyna Oktaba, Alejandro De Las Peñas and Irene Castaño "Chromatin Loop Formation Induced by a Subtelomeric Protosilencer Represses EPA genes in Candida glabrata". GENETICS . 2018;

210 : 113-128

6.- Alejandro Juárez-Reyes and Irene Castaño "Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens. doi: 10.1007/s00294-018-0903-z". CURRENT GENETICS . 2018;

65(2) : 435-443

7.- Osney Leiva-Peláez, Guadalupe Gutiérrez-Escobedo Eunice López-Fuentes, José Cruz-Mora, Alejandro De Las Peñas, Irene Castaño "Molecular characterization of the silencing complex SIR in Candida glabrata hyperadherent clinical isolates https://doi.org/10.1016/j.fgb.2018.05.005". FUNGAL GENETICS AND BIOLOGY . 2018;

118 : 21-31 (en impresión (aceptado))

8.- Gehenna Guerrero-Serrano, Leonardo Castanedo, Gema R. Cristóbal-Mondragón, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Alexander DeLuna, Alejandro De Las Peñas, Irene Castaño, Mónica R. Calera, Roberto Sánchez-Olea "Npa3/ScGpn1 carboxy-terminal tail is dispensable for cell viability and RNA polymerase II nuclear targeting but critical for microtubule stability and function.". BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH . 2017;

1864(3) : 451- 462

9.- David Torres-Tirado, Maureen Knabb, Irene Castaño, Araceli Patrón-Soberano, Alejandro De Las Peñas and Rafael Rubio "Candida glabrata binds to glycosylated and lectinic receptors on the coronary endotelial luminal membrane and inhibits flow sense and cardiac responses to agonists". AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY . 2016;

310 : R24-32

10.- Karina Robledo-Marquez, Guadalupe Gutiérrez-Escobedo, Patricia Yáñez-Carrillo, Yamile Vidal-Aguiar, Marcela Briones-Martín-del-Campo, Emmanuel Orta-Zavalza, Alejandro De Las Peñas, Irene Castaño "Candida glabrata encodes a longer variant of the mating type (MAT) alpha2 gene in the mating type-like MTL3 locus, which can form homodimers. http://dx.doi.org/10.1093/femsyr/fow082". FEMS YEAST RESEARCH . 2016;

16(7)

11.- Patricia Yáñez-Carrillo, Emmanuel Orta-Zavalza, Guadalupe Gutiérrez-Escobedo, Araceli Patrón-Soberano, Alejandro De Las Peñas, Irene Castaño "Expression vectors for C-terminal fusions with fluorescent proteins and epitope tags in Candida glabrata.". FUNGAL GENETICS AND BIOLOGY . 2015;

80 : 43-52

12.- Alejandro De Las Peñas, Jacqueline Juárez-Cepeda, Eunice López-Fuentes, Marcela Briones-Martín-del-Campo, Guadalupe Gutiérrez-Escobedo and Irene Castaño "Local and regional silencing in Candida glabrata: consequences for adhesion and response to stress doi: 10.1093/femsyr/fov056". FEMS YEAST RESEARCH . 2015;

15(6) : 1-9

13.- Emmanuel Orta-Zavalza, Gehenna Guerrero-Serrano, Guadalupe Gutiérrez-Escobedo, Israel Cañas-Villamar, Jacqueline Juárez-Cepeda, Irene Castaño and Alejandro De Las Peñas "Local silencing controls the oxidative stress response and the multidrug resistance in Candida glabrata". MOLECULAR MICROBIOLOGY . 2013;

88(6) : 1135-1148

14.- Guadalupe Gutiérrez-Escobedo, Emmanuel Orta-Zavalza, Irene Castaño, Alejandro De Las Peñas "Role of glutathione in the oxidative stress response in the fungal pathogen Candida glabrata". CURRENT GENETICS . 2013;

59 : 91-106

15.- Verónica Martínez-Jiménez, Candy Y. Ramírez-Zavaleta, Emmanuel Orta-Zavalza, Gabriel Díaz de León, Guadalupe Gutiérrez-Escobedo, Alfredo Ponce de León, José Sifuentes-Osornio, Miriam Bobadilla del Valle, Alejandro De Las Peñas and Irene Castaño "Sir3 Polymorphisms in Candida glabrata Clinical Isolates". MYCOPATHOLOGIA . 2013;

175(4) : 207-219

16.- Verónica Gallegos-García, Shih-Jung Pan, Jacqueline Juárez-Cepeda, Candy Y. Ramírez-Zavaleta, Marcela Briones Martin-del-Campo, Verónica Martínez-Jiménez, Irene Castaño, Brendan Cormack, and Alejandro De Las Peñas "A Novel Downstream Regulatory Element Cooperates With the Silencing Machinery to Repress EPA1 Expression in Candida glabrata". GENETICS . 2012;

190 : 1 - 13

17.- Alejandro Juárez-Reyes, Candy Y. Ramírez-Zavaleta, Luis Medina-Sánchez, Alejandro De Las Peñas and Irene Castaño "A protosilencer of subtelomeric gene expression in Candida glabrata with unique properties". GENETICS . 2012;

190(1) : 101-111 Número de citas: 1

18.- Arroyo-Helguera Omar, De Las Peñas Alejandro and Irene Castaño "Occurrence of killer Candida glabrata clinical isolates". BRAZILIAN JOURNAL OF MICROBIOLOGY . 2012;

43(3) : 880-887

19.- Ramírez-Zavaleta Candy Y., Salas-Delgado Griselda E., De Las Peñas Alejandro and Castano Irene "Subtelomeric silencing of the MTL3 locus of Candida glabrata requires yKu70, yKu80 and Rif1 proteins". EUKARYOTIC CELL . 2010;

9(10) : 1602-1611 Número de citas: 2

20.- Lavaniegos-Sobrino María Teresa, Ramírez-Zavaleta Candy Y., Ponce de León Alfredo, Sifuentes-Osornio José, Bobadilla-del Valle Miriam, Rangel-Cordero Andrea, De Las Peñas Alejandro and Castaño Irene "Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates". MEMORIAS DO INSTITUTO OSWALDO CRUZ . 2009;

104(5) : 775-782

21.- Mayra Cuéllar-Cruz Irene Castaño, Omar Arroyo-Helguera, Alejandro De Las Peñas1 "Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata". MEMORIAS DO INSTITUTO OSWALDO CRUZ . 2009;

104 : 649-654 Número de citas: 3

22.- Mayra Cuéllar-Cruz, Marcela Briones-Martin-del-Campo, Israel Cañas-Villamar, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Irene Castaño, and Alejandro De Las Peñas "High resistance to oxidative stress in the fungal pathogen Candida glabrata is mediated by the single catalase, Cta1p, and controlled by the transcription factors Yap1p, Skn7p, Msn2p and Msn4p ". EUKARYOTIC CELL . 2008;

7(5) : 814-825

23.- Lluvia L. Rosas-Hernández, Alejandro Juárez-Reyes, Omar E. Arroyo-Helguera, Alejanadro De Las Peñas, Shih-Jung Pan, Brendan P. Cormack and Irene Castaño "yKu70/80 and Rif1 regulate silencing differentially at telomeres in Candida glabrata". EUKARYOTIC CELL . 2008;

7 (12) : 2168-2178 Número de citas: 11

24.- Renée Domergue, Irene Castaño, Alejandro De Las Peñas, Margaret Zupancic, Virginia Lockatell, J. Richard Hebel, David Johnson, Brendan P. Cormack. "Nicotinic Acid Limitation Regulates Silencing of Candida Adhesins During UTI". SCIENCE . 2005;

308 : 866-870 Número de citas: 80

25.- Irene Castaño, Shih-Jung Pan, Margaret Zupancic, Christophe Hennequin, Bernard Dujon and Brendan P. Cormack "Telomere length control and transcriptional regulation of sub-telomeric adhesins in Candida glabrata". MOLECULAR MICROBIOLOGY . 2005;

55(4) : 1246-1258 Número de citas: 52

26.- Rupinder Kaur, Irene Castaño, and Brendan Cormack "Functional Genomic Analysis of Fluconazole Susceptibility in the Pathogenic Yeast Candida glabrata: Roles of Calcium Signaling and Mitochondria". ANTIMICROBIAL AGENTS AND CHEMOTHERAPY . 2004;

48(5) : 1600-1613 Número de citas: 57

27.- Irene Castaño, Rupinder Kaur, Shihjung Pan, Robert Cregg, Alejandro De Las Peñas, Nini Guo, Matt Biery, Nancy Craig, and Brendan P. Cormack. "Tn-7-based genome¿wide random insertional mutagenesis of Candida glabratra.". GENOME RESEARCH . 2003;

13 : 905-915 Número de citas: 29

28.- Alejandro De Las Peñas, Shih-Jung Pan, Irene Castaño, John Adler, Robert Cregg and Brendan Cormack "Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in sub-telomeric clusters and subject to RAP1-and SIR-dependent transcriptional silencing". GENES & DEVELOPMENT . 2003;

17(18) : 2245-2258 Número de citas: 103

29.- Brendan Cormack and Irene Castaño "Introduction of point mutations into cloned genes. In: Guide to yeast genetics and molecular and cellular biology. Part B.". METHODS IN ENZYMOLOGY . 2002;

350 : 199-218 Número de citas: 10

30.- Zhenghe Wang, Irene B. Castaño, Carrie Adams, Clemence Vu, David Fitzhugh, and Michael F. Christman "Structure/Function Analysis of the Saccharomyces cerevisiae Trf4/Pol ? DNA Polymerase". GENETICS . 2002;

160(2) : 381-391 Número de citas: 24

31.- Zhenghe Wang, Irene B. Castaño, Alejandro De Las Peñas, Carrie Adams and Michael F. Christman "Pol ?: a DNA polymerase required for sister chromatid cohesion". SCIENCE . 2000;

289(5480) : 774-779 Número de citas: 146

32.- Carrie Walowsky, David J. Fitzhugh, Irene B. Castaño, Justina Y. Ju., Nikki A. Levin "The Topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin". JOURNAL OF BIOLOGICAL CHEMISTRY . 1999;

274(11) : 7302-7308 Número de citas: 57

33.- Irene B. Castaño, Sharon Heath-Pagliuso, Ben U. Sadoff, David J. Fitzhugh and Michael F. Christman "A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation". NUCLEIC ACIDS RESEARCH . 1996;

24(12) : 2404-2410 Número de citas: 55

34.- Irene B. Castaño, Pius M. Brzoska, Ben U. Sadoff, Hongying Chen and Michael F. Christman "Mitotic chromosome condensation in the rDNA requires DNA-topisomerase I and TRF4 in Saccharomyces cerevisiae". GENES & DEVELOPMENT . 1996;

10(20) : 2564-2576 Número de citas: 83

35.- Ben U. Sadoff, Sharon Heath-Pagliuso, Yingfang Zhu, Irene B. Castaño, F.Scott Kieff and Michael F. Christman "Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomeraseI". GENETICS . 1995;

141(2) : 465-479 Número de citas: 51

36.- Irene Castaño, Noemí Flores, Fernando Valle, Alejandra Covarrubias and Francisco Bolívar "gltF, a member of the gltBDF operon, is involved in nitrogen regulated gene expression". MOLECULAR MICROBIOLOGY . 1992;

6 : 2733-2741 Número de citas: 26

37.- Castaño Irene, Fernando Bastarrachea and Alejandra A. Covarrubias "gltBDF operon of Escherichia coli". JOURNAL OF BACTERIOLOGY . 1988;

170(2) : 821-827 Número de citas: 36

38.- Irene Castaño and Fernando Bastarrachea "glnF-lacZ fusions in Escherichia coli: Studies on glnF expression and its chromosomal orientation". MOLECULAR GENETICS AND GENOMICS . 1984;

195(1-2) : 228-233 Número de citas: 37

Publicaciones en otros índices internacionales

1.- Claire Lacombe, Estefania Aleman-Navaro, Thierry Drujon, , Lorena Elizabeth Fajardo Brigido, Yannick Fleury, Christophe Piesse, Guadalupe Gutiérrez-Escobedo, Alejandro De Las Peñas, Irene Castano, Yvonne Rosenstein and Constance Auvynet "Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor". International Journal of Inflammation . 2024;

2024 : 2205864

2.- Bea Timmerman, Alejandro De Las Peñas, Irene Castaño and Patrick Van Dijck "Adhesins in Candida glabrata. doi:10.3390/jof4020060". Journal of Fungi . 2018;

4 : 2-16